How Long Does Trazodone Stay In Your System Reddit

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How Long Does Trazodone Stay in Your System (Reddit)?

Trazodone, an antidepressant belonging to the serotonin antagonist and reuptake inhibitor (SARI) class of medications, is commonly prescribed for treating depression, anxiety, and insomnia. Many users on Reddit, a popular social news aggregation and discussion website, inquire about the duration that trazodone remains in their system. This article aims to provide a comprehensive understanding of trazodone’s pharmacokinetics, elimination mechanisms, and factors affecting its systemic presence.

Trazodone’s Elimination Half-Life and Metabolism

After oral administration, trazodone is rapidly absorbed, reaching peak plasma concentrations within 1 to 2 hours. It undergoes extensive metabolism in the liver, primarily by CYP3A4 and CYP2D6 isoenzymes. The major metabolite, m-chlorophenylpiperazine (mCPP), is pharmacologically active and contributes to the therapeutic effects of trazodone.

The elimination half-life of trazodone in adults ranges from 5 to 13 hours, indicating that approximately half of the drug is eliminated every 5-13 hours. However, this half-life can vary significantly based on individual factors such as age, hepatic function, and concomitant medications.

Factors Affecting Trazodone Elimination

Age: Elderly individuals tend to have a slower metabolism, resulting in a longer elimination half-life of trazodone.

Hepatic Function: Liver impairment can significantly impair trazodone’s metabolism and elimination, leading to increased systemic exposure and potential side effects.

Concomitant Medications: Certain medications, such as CYP3A4 and CYP2D6 inhibitors, can interfere with trazodone’s metabolism, altering its elimination half-life.

Duration of Trazodone in Urine and Blood

Trazodone and its metabolites can be detected in urine for several days after the last dose. Urine drug screening typically detects trazodone for up to 4-5 days.

In blood, trazodone concentrations are typically below detectable levels within 24-48 hours after the last dose. However, in individuals with impaired hepatic function or concomitant medications, blood levels may remain detectable for longer periods.

Tips and Expert Advice

Follow Prescribed Dosage: Adhere strictly to the dosage prescribed by your healthcare provider. Exceeding the recommended dosage can increase systemic exposure and potential side effects.

Consider Metabolism Factors: Be aware of your age, hepatic function, and other medications you are taking, as they can affect trazodone’s elimination. Discuss any potential interactions with your healthcare provider.

Avoid Alcohol: Alcohol can inhibit trazodone’s metabolism, leading to increased systemic exposure. Limit or avoid alcohol consumption while taking trazodone.

Monitor Symptoms: Pay attention to how trazodone affects you. If you experience unusual side effects, such as excessive drowsiness, confusion, or hallucinations, consult your healthcare provider immediately.

Common Concerns and FAQs

Q: How long before trazodone is out of my system completely?
A: The complete elimination of trazodone from the body typically takes 5-13 hours, but can vary depending on individual factors.

Q: Can trazodone be detected in a urine drug test?
A: Yes, trazodone and its metabolites can be detected in urine typically for 4-5 days after the last dose.

Q: How long before trazodone stops working?
A: The therapeutic effects of trazodone usually last for 6-8 hours. However, the duration may vary depending on the individual and the reason for taking the medication.

Q: What happens if I take too much trazodone?
A: Overdosing on trazodone can be dangerous, potentially leading to seizures, coma, and respiratory depression. Seek immediate medical attention if you suspect an overdose.


Understanding how long trazodone stays in your system is essential for managing its use effectively and minimizing potential risks. By following prescribed dosages, considering metabolic factors, and monitoring symptoms, you can optimize the therapeutic benefits while ensuring safety.

Are you interested in learning more about trazodone or other medications for depression, anxiety, and insomnia? Explore our comprehensive blog resources and connect with our community of experts for evidence-based information and support.

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